Endocrine Abstracts

Functional hypothalamic amenorrhoea (FHA) is a disorder associated with functional inhibition of the hypothalamic-pituitary-ovarian axis due to deficiency of pulsatile GnRH. The incidence of FHA ranges from 15 to 48% of all secondary amenorrheas. The abnormal GnRH secretion leads to decreased pulses of gonadotropins, absent midcycle surges in luteinizing hormone (LH) secretion, absence of normal follicular development, anovulation, and low estradiol (E2). Causes of FHA can be ...

Adrenal vein sampling (AVS) is the gold standard for detecting aldosterone production in bilateral adrenal hyperplasia and for distinguishing the lateralization of aldosterone secretion. Successful AVS is determined by calculating the selectivity index (SI). The cut off value for the SI is ≥2.0 under un-stimulated conditions. The aldosterone level (AL) is corrected for cortisol level (CL) and adjusted values are then compared to determine the lateralizing index (LI). Mos...